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The Cellular Imaging Core provides state-of-the-art microscopy facilities and full technical support for quantitative fluorescence imaging experiments for all scientists (and visitors) working within the Centre.

Resources and Facilities

core-main-picture.jpgThe Cellular Imaging Core offers cutting edge techniques for:

Microscopy

  • Fluorescence Correlation Spectroscopy (FCS)
  • Fluorescence Lifetime Correlation Spectroscopy (FLCS)
  • Fluorescence Lifetime Imaging Microscopy (FLIM)
  • Total Internal Reflection Fluorescence Microscopy (TIRF)
  • Photoactivated Localization Microscopy (PALM)
  • Spectral Imaging (SI) and Single Particle Tracking (SPT)

Computing

We have a public access PC workstation with various software packages for spectroscopy data analysis and quantitative imaging.

Research and Development

We develop novel techniques for quantitative imaging, and we have a particular interest in the detection and quantification of protein-protein interactions within living cells.

Current developments include Spatio-Temporal Fluctuation Correlation Spectroscopy, Single Particle Tracking, Fluorescence Lifetime Imaging Microscopy (fast-FLIM) and Super-Resolution Localization Microscopy.

Nobel Prize Winning Microscopy Techniques at the WTCHG Cellular-Imaging Core

Eric Betzig (The Howard Hughes Medical Institute), William Moerner (Stanford University) and Stefan Hell (The Max Planck Institute) have been awarded the 2014 Nobel Prize in Chemistry for their recent work on super-resolution fluorescence microscopy.

Eric Betzig recieved the Nobel Prize for his pioneering work on PALM (Photo-Activated Laser Microscopy), and the PALM/STORM super-resolution technique is available on our Zeiss Elyra microscope. William Moerner recieved his Nobel prize for the development of laser spectroscopy and microscopy to detect single molecules and so probe biological processes, one biomolecule at a time. We are working with this advanced technique on our SP8-X Single Molecule Detection (SMD) confocal microscope.

Core Members

Core Head : Dr Sergi Padilla-Parra

To Contact us

For general inquiries, and to arrange microscope training, please email us at cellular-imaging@well.ox.ac.uk. Our telephone number is: 01865 287568 - the Core laboratory.