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Publications

Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis

Brown M. et al, (2023), EMBO Molecular Medicine

Author Correction: Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features

Flanagan DJ. et al, (2023), Nature Communications, 14

Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features

Flanagan DJ. et al, (2022), Nature Communications, 13

Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia.

Vasquez EG. et al, (2022), Cell stem cell, 29, 1213 - 1228.e8

Molecular phenotyping of colorectal neoplasia shows dynamic and adaptive cancer stem cell population admixture

Vazquez EG. et al, (2022)

BMP pathway antagonism by Grem1 regulates epithelial cell fate in intestinal regeneration

Koppens MAJ. et al, (2021)

Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification

Kleeman SO. et al, (2020), Gut, 69, 1092 - 1103

Stabilising selection causes grossly altered but stable karyotypes in metastatic colorectal cancer

Cross W. et al, (2020)

The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression.

Thomas R. et al, (2019), Scientific reports, 9

Evolutionary history of human colitis-associated colorectal cancer

Baker A-M. et al, (2019), Gut, 68, 985 - 995

The evolutionary landscape of colorectal tumorigenesis

Cross W. et al, (2018), Nature Ecology & Evolution, 2, 1661 - 1672

Bone morphogenetic protein and Notch signalling crosstalk in poor-prognosis, mesenchymal-subtype colorectal cancer

Irshad S. et al, (2017), The Journal of Pathology, 242, 178 - 192

Regulation of BRAF protein stability by a negative feedback loop involving the MEK–ERK pathway but not the FBXW7 tumour suppressor

Hernandez MA. et al, (2016), Cellular Signalling, 28, 561 - 571

Mechanisms of action of bone morphogenetic proteins in cancer

Davis H. et al, (2016), Cytokine & Growth Factor Reviews, 27, 81 - 92

Microenvironmental control of stem cell fate in intestinal homeostasis and disease

Biswas S. et al, (2015), The Journal of Pathology, 237, 135 - 145

Microenvironmental control of stem cell fate in intestinal homeostasis and disease

Biswas S. et al, (2015), Journal of Pathology, 237, 135 - 145

Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche

Davis H. et al, (2015), Nature Medicine, 21, 62 - 70

A Polymorphic Enhancer near GREM1 Influences Bowel Cancer Risk through Differential CDX2 and TCF7L2 Binding

Lewis A. et al, (2014), Cell Reports, 8, 983 - 990

Aberrant Epithelial GREM1 Expression Promotes Stem-Cell Plasticity and Ectopic Crypt Formation in the Pathogenesis of Familial and Sporadic Human Polyps

Davis HL. et al, (2014), GASTROENTEROLOGY, 146, S86 - S86

Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines

Davis H. et al, (2014), Gut, 63, 792 - 799

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