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One form of maturity-onset diabetes of the young, Type 3 (MODY3), results from mutations in the gene coding for hepatocyte nuclear factor-1alpha (HNF-1alpha), a transcription factor first described in the liver. MODY3 is characterized by a defective glucose-stimulated insulin secretion. Earlier observations of glycosuria with normal blood glucose levels in some MODY families suggest an additional renal manifestation of the respective genetic defect. We measured the renal threshold for glucose in five diabetic carriers of a missense mutation (Arg 272 His) in HNF-1alpha and, for comparison, in eight Type 1 diabetic patients, applying a non-invasive protocol of frequent parallel blood and urine sampling during a slow shift in blood glucose levels. We found that the mean renal threshold for glucose was lowered in the HNF-1alpha diabetic patients compared to those with Type 1 diabetes (6.5 +/- 0.9 mmol l(-1) vs 10.7 +/- 0.5 mmol l(-1); p < 0.01). This lowered glucose threshold might be an indication of an extra-pancreatic effect of HNF-1alpha gene mutations in humans. Defects in HNF-1alpha may lead to an altered tubular glucose reabsorption, possibly due to decreased expression of the renal glucose transporter proteins involved in reabsorption of glucose from the urine.

Original publication

DOI

10.1002/(sici)1096-9136(199810)15:10&lt;816::aid-dia714&gt;3.0.co;2-p

Type

Journal article

Journal

Diabetic medicine : a journal of the British Diabetic Association

Publication Date

10/1998

Volume

15

Pages

816 - 820

Addresses

Klinikum Karlsburg, Germany. ruth.menzel@greifswald.netsurf.de

Keywords

Kidney Tubules, Humans, Diabetes Mellitus, Type 1, Glycosuria, Glucose, Blood Glucose, DNA-Binding Proteins, Nuclear Proteins, Transcription Factors, Polymerase Chain Reaction, Pedigree, Absorption, Biological Transport, Mutation, Missense, Adolescent, Adult, Aged, Female, Male, Hepatocyte Nuclear Factor 1, Hepatocyte Nuclear Factor 1-alpha, Hepatocyte Nuclear Factor 1-beta