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The blood pressure (BP) lowering effect of low doses of antihypertensive agents is not usually explored because of the difficulty in detecting small changes in BP. Since ambulatory blood pressure monitoring in a cross-over trial design can reliably detect differences of 5 mmHg with less than 20 subjects, we have used this technique to assess the dose-response curve of a new beta-blocker, carvedilol. Twenty subjects were enrolled after diagnostic ambulatory BP monitoring had shown a day-time average diastolic BP of over 90 mmHg. Three doses of carvedilol (6.25, 12.5 and 25 mg daily) and placebo were then given double-blind in random order for periods of 4 weeks each. No period effects were detected. The antihypertensive effect was statistically significant at doses of 12.5 mg and 25 mg daily. There was, however, no evidence that 25 mg/day produced the peak effect. The lowest dose (6.25 mg/day) produced a small fall in both systolic and diastolic BP but neither of these were significant. We conclude that doses of 12.5 and 25 mg carvedilol once a day are adequate for the treatment of hypertension.

Original publication

DOI

10.1007/bf00207609

Type

Journal article

Journal

The Clinical investigator

Publication Date

01/1992

Volume

70 Suppl 1

Pages

S37 - S38

Addresses

Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford.

Keywords

Humans, Hypertension, Propanolamines, Carbazoles, Adrenergic beta-Antagonists, Antihypertensive Agents, Vasodilator Agents, Drug Administration Schedule, Blood Pressure Monitors, Blood Pressure, Dose-Response Relationship, Drug, Adult, Carvedilol