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Genomic studies revealed two main components in the genetic architecture of schizophrenia, one constituted by common variants determining a distributed polygenic effect and one represented by a large number of heterogeneous rare and highly disruptive mutations. These gene modifications often affect neural transmission and different studies proved an involvement of metabotropic glutamate receptors in schizophrenia phenotype. Through the combination of literature information with genomic data from public repositories, we analyzed the current knowledge on the involvement of genetic variations of the human metabotropic glutamate receptors in schizophrenia and related endophenotypes. Despite the analysis did not reveal a definitive connection, different suggestive associations have been identified and in particular a relevant role has emerged for GRM3 in affecting specific schizophrenia endophenotypes. This supports the hypothesis that these receptors are directly involved in schizophrenia disorder.

Original publication

DOI

10.2174/1570159x13666150514232745

Type

Journal article

Journal

Current neuropharmacology

Publication Date

01/2016

Volume

14

Pages

540 - 550

Keywords

Humans, Receptors, Metabotropic Glutamate, Antipsychotic Agents, Schizophrenia, Endophenotypes