Miles Carroll
Research groups
Miles Carroll
HOST-PATHOGEN INTERACTIONS OF HIGH CONSEQUENCE EMERGING VIRUSES
Our work centres around high consequence emerging viral infections. Currently, our focus is on Ebola, Lassa fever and SARS-CoV-2. We are interested in host-pathogen interactions, development of anti-virals and recently we have been looking at the IgG response following SARS-CoV-2 infection and/or vaccination in humans and animal models. To further support this work we are using a live virus neutralisation, multiplex immunoassays and novel ACE2 inhibition assay to inform on the ability of serum to neutralise SARS-CoV-2 variants of concern (VOC). We are also interested in the innate response to viral infection, particularly activation and/or evasion of the complement system
Recent publications
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Linked Mutations in the Ebola Virus Polymerase Are Associated with Organ Specific Phenotypes.
Journal article
Dong X. et al, (2023), Microbiol Spectr
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Evolution of long-term vaccine-induced and hybrid immunity in healthcare workers after different COVID-19 vaccine regimens.
Journal article
Moore SC. et al, (2023), Med (N Y)
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Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine
Journal article
Brewitz L. et al, (2023), Journal of Medicinal Chemistry
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Influence of Landscape Patterns on Exposure to Lassa Fever Virus, Guinea
Journal article
Longet S. et al, (2023), Emerging Infectious Diseases, 29, 304 - 313
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Pre-clinical models to define correlates of protection for SARS-CoV-2.
Journal article
Brady C. et al, (2023), Frontiers in immunology, 14