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Dr Lahiru Handunnetthi

Clinical Research Fellow


Dr Handunnetthi’s research focuses on understanding how human genetic variation contributes to neurological disease and how knowledge of such genetic risk factors can be used to identify novel drug targets. His particular interests are in the inflammatory diseases of the central nervous system such as multiple sclerosis and also in other diseases such as schizophrenia, where inflammation is playing a newly emerging role.

He is specifically involved in the functional characterisation of genetic risk alleles discovered through genome wide association studies, application of epigenetic information to identify disease relevant cell types and integration of various forms of genomic data to discover new drug targets.  

Dr Handunnetthi completed his DPhil at the Wellcome Centre for Genetics, University of Oxford. His work focused on understanding the interactions between genetic and environmental risk factors in multiple sclerosis. He studied medicine at the University of Cambridge and currently holds a NIHR funded Academic Clinical Fellowship in Neurology. He is open to collaboration both in academia and the pharmaceutical industry.

Key words: Multiple Sclerosis, Schizophrenia, Genetics, Drug Target, Chromatin