Chris O'Callaghan

Professor of Medicine, Honorary Consultant Physician and Nephrologist, Fellow of The Queen's College

The immune system plays a major role in many human diseases, including cancer, infection, atherosclerosis and autoimmune disease. A better understanding of the immune system should accelerate the design of better treatments for these diseases.

We study the function of the molecules and pathways involved in the immune response and the role of the immune system and inflammation in disease. The group employs a wide range of approaches to understand basic biology and disease mechanisms.

Recent publications

Frequency of Renal Monitoring — Creatinine and Cystatin C (FORM-2C): an observational cohort study of patients with reduced eGFR in primary care
Journal article

Fleming S. et al, (2021), British Journal of General Practice, 71, e677 - e684
Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling.
Journal article

Trauelsen M. et al, (2021), Cell reports, 35
Prevalence and factors associated with multimorbidity among primary care patients with decreased renal function
Journal article

Hirst JA. et al, (2021), PLOS ONE, 16, e0245131 - e0245131
The Role of Metabolite-Sensing G Protein-Coupled Receptors in Inflammation and Metabolic Disease
Journal article

Recio C. et al, (2018), Antioxidants & Redox Signaling, 29, 237 - 256
Activation of the Immune-Metabolic Receptor GPR84 Enhances Inflammation and Phagocytosis in Macrophages
Journal article

Recio C. et al, (2018), Frontiers in Immunology, 9

More publications