Oxford-Janssen Postdoctoral Fellow (Cartography, Bioinformatics)
Charlotte Rich-Griffin is the bioinformatics postdoctoral research fellow with the Oxford-Janssen Cartography project. She is a computational biologist who specialises in the analysis of single cell experiments and joined the Dendrou group at the WHG in March 2020.
Prior to Cartography, Charlotte worked on the COvid-19 Multi-omics Blood ATlas (COMBAT), specifically focussing on processing, clustering and composition analysis of CITE-seq data. This cross-Oxford collaboration involved profiling of 120 patients with different severities of Covid-19 plus flu and sepsis comparators. The project aim to characterise the clinical heterogeneity and increase the understanding of potentially druggable immune mediators of Covid-19.
Her other work with the Dendrou group has involved analysing experiments that aim to understand how immune cell composition and function can be resolved at the single-cell level in primary human tissues including gut and brain, to help inform therapeutic strategies.
Previously, Charlotte worked at the WIMM researching cancer-specific T cells with Tao Dong and Hashem Koohy. Her work focused on integrating TCR repertoire information with gene expression in order to identify cancer specific subsets of T cells.
Prior to that, Charlotte achieved her PhD from the University of Warwick. Unlike her current research into human immunity, her PhD research focussed on plant immunity. Her thesis "Cell-type specific transcriptomics of immunity in Arabidopsis thaliana roots" was supervised by Professor Patrick Shafer and Dr Sascha Ott.
ORCID ID: https://orcid.org/0000-0001-8212-9542
An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease
Peng Y. et al, (2021), Nature Immunology
Plant circadian clock control of Medicago truncatula nodulation via regulation of Nodule Cysteine-Rich peptides
Achom M. et al, (2021), Journal of Experimental Botany
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity
Ahern DJ. et al, (2021)
Regulation of Cell Type-Specific Immunity Networks in Arabidopsis Roots
Rich-Griffin C. et al, (2020), The Plant Cell, 32, 2742 - 2762
Single-Cell Transcriptomics: A High-Resolution Avenue for Plant Functional Genomics
Rich-Griffin C. et al, (2020), Trends in Plant Science, 25, 186 - 197