Dr Carla Cohen
Ankylosing spondylitis (AS) is a chronic inflammatory arthritis affecting 1-2% of people in the UK. It is a polygenic disease, with over 40 associated genetic loci identified by genome-wide association studies. My research focus is to determine which particular single nucleotide polymorphisms (SNPs) play a causative role in the pathogenesis of AS. We have performed comprehensive epigenomic profiling of lymphocyte populations in AS patients and healthy controls. We are now analysing these data to identify how differential chromatin regions are linked to loci that are genetically associated with AS. Understanding these regulatory mechanisms may lead to the development of novel therapies for this debilitating condition.
I completed my DPhil at Oxford and went on to a postdoctoral position with Prof Dixie Mager, where I studied regulatory elements involving transposable elements, in Vancouver, Canada. During that time I developed an interest in epigenetic regulation which led me to return to Oxford and join Prof Wordsworth’s research group. In 2019 I joined Julian Knight's research team.
I am funded on a grant from Wyeth Pharmaceuticals and recently obtained awards from the University of Oxford Returning Carers’ Fund and the COVID Rebuilding Research Momentum Fund.
Twitter: @DrCarlaCohen @KnightGenetics
Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis
Brown AC. et al, (2023), Cell Genomics, 3, 100306 - 100306
Chromosome conformation capture approaches to investigate 3D genome architecture in Ankylosing Spondylitis
Davidson C. et al, (2023), Frontiers in Genetics, 14
Disruption of c-MYC Binding and Chromosomal Looping Involving Genetic Variants Associated With Ankylosing Spondylitis Upstream of the RUNX3 Promoter
Cohen CJ. et al, (2022), Frontiers in Genetics, 12
FUNCTIONAL GENOMICS INVESTIGATION OF THE ANKYLOSING SPONDYLITIS ASSOCIATED LOCUS RUNX3
Cohen C. et al, (2022), ANNALS OF THE RHEUMATIC DISEASES, 81, 231 - 231
INVESTIGATING THE ANKYLOSING SPONDYLITIS-ASSOCIATED REGULATORY SNPS AT THE RUNX3 LOCUS WITH A FUNCTIONAL GENOMICS APPROACH
Vecellio M. et al, (2021), ANNALS OF THE RHEUMATIC DISEASES, 80, 411 - 411