28 June 2019
Identifying targets for drug development is hard with high failure rates in later-stage clinical trials. A new study led by Professor Julian Knight at the Wellcome Centre for Human Genetics and colleagues from the ULTRA-DD Consortium shows how genetics combined with knowledge of network connectivity can help. The new Priority Index or ‘Pi’ pipeline developed by first-author Dr Hai Fang is open-source and scalable, enabling other researchers to capitalise on their findings. The paper, published today in Nature Genetics, describes the drug target prioritisation landscape for 30 different immune-mediated diseases.
25 March 2019
A new paper, published in Science, looks at factors influencing meiotic recombination revealed by whole-genome sequencing of single sperm
7 February 2019
A new study into the genetic makeup of over 1,400 individuals from across Spain has shown that the genetic patterns in modern individuals were shaped by population movements over the past 1,000 years. It also showed that in some regions, there are discernible patterns of genetic differences even between individuals living as close as 10km apart.
17 December 2018
Centre PI, Prof Peter Donnelly, was part of the Royal Society "You and AI" panel discussion. You can watch the entire event, chaired by Brian Cox, online
20 November 2018
Wellcome Centre for Human Genetics researcher Dr Ross Chapman has been selected as one of the European Molecular Biology Organisation's Young Investigators for 2018.
11 October 2018
Genetics of brain structure and development, and a description of the largest human genetic study ever undertaken feature in this week’s Nature journal
3 August 2018
Three GMS students from the WCHG recently competed in the Wellcome-Sanger Institute’s inaugural BioData Hackathon (#BioDataHack) and took home the top prize in their category.