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From bugs to drugs

From bugs to drugs

Research

Decoding the pharmacological goldmine in tick saliva.

New wchg director

NEW WHG Director

Leveraging genetics to help inform drug target discovery

Leveraging genetics to help inform drug target discovery

Identifying targets for drug development is hard with high failure rates in later-stage clinical trials. A new study led by Professor Julian Knight at the Wellcome Centre for Human Genetics and colleagues from the ULTRA-DD Consortium shows how genetics combined with knowledge of network connectivity can help. The new Priority Index or ‘Pi’ pipeline developed by first-author Dr Hai Fang is open-source and scalable, enabling other researchers to capitalise on their findings. The paper, published today in Nature Genetics, describes the drug target prioritisation landscape for 30 different immune-mediated diseases.

Factors influencing meiotic recombination revealed by whole genome sequencing of single sperm

Factors influencing meiotic recombination revealed by whole-genome sequencing of single sperm

A new paper, published in Science, looks at factors influencing meiotic recombination revealed by whole-genome sequencing of single sperm

Centuries old population movements revealed in fine scale genetic map of the iberian peninsula

Centuries-old population movements revealed in fine-scale genetic map of the Iberian Peninsula

A new study into the genetic makeup of over 1,400 individuals from across Spain has shown that the genetic patterns in modern individuals were shaped by population movements over the past 1,000 years. It also showed that in some regions, there are discernible patterns of genetic differences even between individuals living as close as 10km apart.

Watch prof peter donnelly speak at royal society ai event

Watch Prof Peter Donnelly speak at Royal Society AI event

Centre PI, Prof Peter Donnelly, was part of the Royal Society "You and AI" panel discussion. You can watch the entire event, chaired by Brian Cox, online

Dr ross chapman welcomed as embo young investigator

Dr Ross Chapman welcomed as EMBO Young Investigator

Research

Wellcome Centre for Human Genetics researcher Dr Ross Chapman has been selected as one of the European Molecular Biology Organisation's Young Investigators for 2018.

Uk biobank genetics opens the door to a new era of health research

UK Biobank genetics opens the door to a new era of health research

Genetics of brain structure and development, and a description of the largest human genetic study ever undertaken feature in this week’s Nature journal

Shieldin complex

Shieldin Complex

Dphil gms students win astrazeneca challenge at biodatahack

DPhil GMS Students win AstraZeneca challenge at #BioDataHack

Three GMS students from the WCHG recently competed in the Wellcome-Sanger Institute’s inaugural BioData Hackathon (#BioDataHack) and took home the top prize in their category.

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