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Our supervisors undertake research across 7 core themes:

1. Genomic and -omic technologies

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Rachael Bashford-Rogers

We aim to determine the development, regulation and function of B and T cell populations in health and immunological diseases to lead us to an understanding of why certain individuals are at greater risk of developing immunological disease, as well as to identify potential therapeutic targets or improve clinical management. 

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Daniel Ebner

 

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Sally Cowley

We use human induced Pluripotent Stem Cells to model disease, focussing on innate immunity and neuroinflammation, with opportunities to undertake CRISPR/Cas-mediated mutagenesis and screens to uncover disease-associated pathways.   

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James McCullagh

Our group focuses on how chemical relationships between biomolecules are linked to their function in complex biological systems with particular focus on metabolism and its perturbations in health and disease. 

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Deborah Gill

We use viral vectors, which target the lung and liver, to deliver genes and gene editing molecules for treatment of rare diseases. 

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Sergi Padilla-Parra

Use of advanced imaging to understand HIV entry.

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Ben Davies

Our group researches the utility of CRISPR/Cas9 genome editing techniques to facilitate the generation of model systems, allowing the functional consequences of genome variation and mutation to be explored.

Benedikt Kessler

 

2. Functional genomics

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Gerton Lunter

We develop deep learning methods to predict genome function from sequence, to assess the impact of sequence variants and to improve our understanding of basic biology.

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Calli Dendrou

Our research aims to determine (i) how pleiotropic genetic variation affects immune responses in health and disease and (ii) how immune cell composition and function can be resolved at the single-cell level in primary human tissues to help inform therapeutic strategies. 

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Doug Higgs

We use state of the art technologies in molecular biology, imaging and computational analysis to establish the principles by which mammalian genes are switched on and off during lineage specification, differentiation and maturation. 

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John Todd

The JDRF/Wellcome Trust DIL is researching the causes of the autoimmune disease type 1 diabetes (T1D) in order to treat and prevent the disease by modulating the causative pathways.  

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Ben Davies

Our group researches the utility of CRISPR/Cas9 genome editing techniques to facilitate the generation of model systems, allowing the functional consequences of genome variation and mutation to be explored.

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Jim Hughes

The Hughes group combines molecular, computational and machine learning based approaches to investigate mammalian gene regulation and  the role sequence variation plays in common human disease. 

Julian Knight

Thomas Milne

Tatjana Sauka-Spengler

 

3. Genome biology

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Daniel Wilson

We research the population genomics of pathogenic bacteria, including genome-wide association studies and evolutionary approaches.

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Adrian Smith

Our lab has a main focus on molecular immunology and infectious disease particularly from a comparative perspective including modern and ancient (archaeological) datasets.

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Cath Green

Our group studies somatic genome instability and the causes and consequences of mutation and genomic change.

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Greger Larson

We extract, amplify, and analyse ancient DNA derived from archaeological and palaentological specimens to directly assess the evolution of animals and pathogens through time and space.

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Pier Palamara

Our group develops new statistical and machine learning methods to enable novel analyses in population and disease genetics, with a particular interest in problems that involve large genomic datasets. 

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Doug Higgs

We use state of the art technologies in molecular biology, imaging and computational analysis to establish the principles by which mammalian genes are switched on and off during lineage specification, differentiation and maturation.

Ross Chapman

Adrian Hill

Dominic Kwiatkowski

 

4. Genomics of disease

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Christophe Fraser

We develop high-throughput pathogen genomics, computational analysis and modelling to improve infectious disease prevention, with particular but not exclusive focus on HIV/AIDS.

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Simon Leedham

Our work centres on the morphogenic control of intestinal stem cell fate in health, regeneration and cancer and the preclinical application of novel therapies to manipulate this regulation.

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Katrina Lythgoe

We use a combination of mathematical modelling and the analysis of viral sequence data to better understand how within-host evolution affects how pathogens spread and evolve at the host population level.

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David Wedge

The Wedge group use genomics to study cancer evolution.

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Krina Zondervan

Our group works on understanding the pathogenesis of common women's health disorders through genomic, molecular, and environmental epidemiological research methods.  

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Cecilia Lindgren

The multi-disciplinary Lindgren group apply a wide range of genetics and genomics methods to dissect the causes and consequences of obesity traits as well as related reproductive conditions.

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Sergi Padilla-Parra

Use of advanced imaging to understand HIV entry.

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John Todd

The JDRF/Wellcome Trust DIL is researching the causes of the autoimmune disease type 1 diabetes (T1D) in order to treat and prevent the disease by modulating the causative pathways.  

Barbara Casadei

Benjamin Fairfax

Keith Channon

David Church

Ellie Tzima

Hugh Watkins

 

5. Genomic analysis

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Christophe Fraser

We develop high-throughput pathogen genomics, computational analysis and modelling to improve infectious disease prevention, with particular but not exclusive focus on HIV/AIDS.

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Adrian Smith

Our lab has a main focus on molecular immunology and infectious disease particularly from a comparative perspective including modern and ancient (archaeological) datasets.

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Gerton Lunter

We develop deep learning methods to predict genome function from sequence, to assess the impact of sequence variants and to improve our understanding of basic biology.

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David Wedge

The Wedge group use genomics to study cancer evolution.

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Cecilia Lindgren

The multi-disciplinary Lindgren group apply a wide range of genetics and genomics methods to dissect the causes and consequences of obesity traits as well as related reproductive conditions.

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Greger Larson

We extract, amplify, and analyse ancient DNA derived from archaeological and palaentological specimens to directly assess the evolution of animals and pathogens through time and space.

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Augustine Kong

We are interested in the effects of genetic nurturing, i.e. the genes in a person's relatives (e.g. parents and siblings) influencing their behaviour and social economic status and through that impact the outcomes of the person.

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Pier Palamara

Our group develops new statistical and machine learning methods to enable novel analyses in population and disease genetics, with a particular interest in problems that involve large genomic datasets. 

Jenny Taylor

The BRC Genomic Medicine Theme’s research currently focuses on the application of targeted and whole genome sequencing (WGS) to the diagnosis of rare diseases and cancer, and investigation of novel genes emerging applying a range of functional approaches.

Peter Donnelly

Chris Holmes

Valentina Iotchkova

Simon Myers

 

6. From genes to clinical proof of concept

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Shoumo Bhattacharya

Our goals are to develop therapeutics targeting the chemokine network in inflammatory diseases affecting the heart, blood vessels and other organ systems.”

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Rachael Bashford-Rogers

We aim to determine the development, regulation and function of B and T cell populations in health and immunological diseases to lead us to an understanding of why certain individuals are at greater risk of developing immunological disease, as well as to identify potential therapeutic targets or improve clinical management. 

McCullagh.png

James McCullagh

Our group focuses on how chemical relationships between biomolecules are linked to their function in complex biological systems with particular focus on metabolism and its perturbations in health and disease

Calli-Dendrou.png

Calli Dendrou

Our research aims to determine (i) how pleiotropic genetic variation affects immune responses in health and disease and (ii) how immune cell composition and function can be resolved at the single-cell level in primary human tissues to help inform therapeutic strategies. 

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Zameel Cader

Translation neuroscience using human stem cell models of the brain and advanced informatics.

Andrea Nemeth

Paul Brennan

 

7. Application of genomics in the clinic

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Simon Leedham

Our work centres on the morphogenic control of intestinal stem cell fate in health, regeneration and cancer and the preclinical application of novel therapies to manipulate this regulation.

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Deborah Gill

We use viral vectors, which target the lung and liver, to deliver genes and gene editing molecules for treatment of rare diseases. 

Jenny Taylor

The BRC Genomic Medicine Theme’s research currently focuses on the application of targeted and whole genome sequencing (WGS) to the diagnosis of rare diseases and cancer, and investigation of novel genes emerging applying a range of functional approaches.

Robert MacLaren

Andrew Wilkie

 Prospective students can contact our supervisors directly to ask about specific projects of interest.