Potential Supervisors
Our supervisors undertake research across 7 core themes:
1. Genomic and -omic technologies
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We aim to determine the development, regulation and function of B and T cell populations in health and immunological diseases to lead us to an understanding of why certain individuals are at greater risk of developing immunological disease, as well as to identify potential therapeutic targets or improve clinical management. |
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We use human induced Pluripotent Stem Cells to model disease, focussing on innate immunity and neuroinflammation, with opportunities to undertake CRISPR/Cas-mediated mutagenesis and screens to uncover disease-associated pathways. |
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Our group focuses on how chemical relationships between biomolecules are linked to their function in complex biological systems with particular focus on metabolism and its perturbations in health and disease. |
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We use viral vectors, which target the lung and liver, to deliver genes and gene editing molecules for treatment of rare diseases. |
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Use of advanced imaging to understand HIV entry. |
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Our group researches the utility of CRISPR/Cas9 genome editing techniques to facilitate the generation of model systems, allowing the functional consequences of genome variation and mutation to be explored. |
2. Functional genomics
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We develop deep learning methods to predict genome function from sequence, to assess the impact of sequence variants and to improve our understanding of basic biology. |
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Our research aims to determine (i) how pleiotropic genetic variation affects immune responses in health and disease and (ii) how immune cell composition and function can be resolved at the single-cell level in primary human tissues to help inform therapeutic strategies. |
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We use state of the art technologies in molecular biology, imaging and computational analysis to establish the principles by which mammalian genes are switched on and off during lineage specification, differentiation and maturation. |
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The JDRF/Wellcome Trust DIL is researching the causes of the autoimmune disease type 1 diabetes (T1D) in order to treat and prevent the disease by modulating the causative pathways. |
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Our group researches the utility of CRISPR/Cas9 genome editing techniques to facilitate the generation of model systems, allowing the functional consequences of genome variation and mutation to be explored. |
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The Hughes group combines molecular, computational and machine learning based approaches to investigate mammalian gene regulation and the role sequence variation plays in common human disease. |
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Our group is interested in using multi-omic approaches to understand variation in the immune response to infection and autoimmunity with the goal of advancing personalised medicine and development of new drugs |
3. Genome biology
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We research the population genomics of pathogenic bacteria, including genome-wide association studies and evolutionary approaches. |
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Our lab has a main focus on molecular immunology and infectious disease particularly from a comparative perspective including modern and ancient (archaeological) datasets. |
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Our group studies somatic genome instability and the causes and consequences of mutation and genomic change. |
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We extract, amplify, and analyse ancient DNA derived from archaeological and palaentological specimens to directly assess the evolution of animals and pathogens through time and space. |
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Our group develops new statistical and machine learning methods to enable novel analyses in population and disease genetics, with a particular interest in problems that involve large genomic datasets. |
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We use state of the art technologies in molecular biology, imaging and computational analysis to establish the principles by which mammalian genes are switched on and off during lineage specification, differentiation and maturation. |
4. Genomics of disease
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We develop high-throughput pathogen genomics, computational analysis and modelling to improve infectious disease prevention, with particular but not exclusive focus on HIV/AIDS. |
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Our work centres on the morphogenic control of intestinal stem cell fate in health, regeneration and cancer and the preclinical application of novel therapies to manipulate this regulation. |
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We use a combination of mathematical modelling and the analysis of viral sequence data to better understand how within-host evolution affects how pathogens spread and evolve at the host population level. |
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The Wedge group use genomics to study cancer evolution. |
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Our group works on understanding the pathogenesis of common women's health disorders through genomic, molecular, and environmental epidemiological research methods. |
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The multi-disciplinary Lindgren group apply a wide range of genetics and genomics methods to dissect the causes and consequences of obesity traits as well as related reproductive conditions. |
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Use of advanced imaging to understand HIV entry. |
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The JDRF/Wellcome Trust DIL is researching the causes of the autoimmune disease type 1 diabetes (T1D) in order to treat and prevent the disease by modulating the causative pathways. |
5. Genomic analysis
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We develop high-throughput pathogen genomics, computational analysis and modelling to improve infectious disease prevention, with particular but not exclusive focus on HIV/AIDS. |
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Our lab has a main focus on molecular immunology and infectious disease particularly from a comparative perspective including modern and ancient (archaeological) datasets. |
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We develop deep learning methods to predict genome function from sequence, to assess the impact of sequence variants and to improve our understanding of basic biology. |
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The Wedge group use genomics to study cancer evolution. |
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The multi-disciplinary Lindgren group apply a wide range of genetics and genomics methods to dissect the causes and consequences of obesity traits as well as related reproductive conditions. |
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We extract, amplify, and analyse ancient DNA derived from archaeological and palaentological specimens to directly assess the evolution of animals and pathogens through time and space. |
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We are interested in the effects of genetic nurturing, i.e. the genes in a person's relatives (e.g. parents and siblings) influencing their behaviour and social economic status and through that impact the outcomes of the person. |
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Our group develops new statistical and machine learning methods to enable novel analyses in population and disease genetics, with a particular interest in problems that involve large genomic datasets. |
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The BRC Genomic Medicine Theme’s research currently focuses on the application of targeted and whole genome sequencing (WGS) to the diagnosis of rare diseases and cancer, and investigation of novel genes emerging applying a range of functional approaches. |
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6. From genes to clinical proof of concept
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Our goals are to develop therapeutics targeting the chemokine network in inflammatory diseases affecting the heart, blood vessels and other organ systems.” |
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We aim to determine the development, regulation and function of B and T cell populations in health and immunological diseases to lead us to an understanding of why certain individuals are at greater risk of developing immunological disease, as well as to identify potential therapeutic targets or improve clinical management. |
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Our group focuses on how chemical relationships between biomolecules are linked to their function in complex biological systems with particular focus on metabolism and its perturbations in health and disease |
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Our research aims to determine (i) how pleiotropic genetic variation affects immune responses in health and disease and (ii) how immune cell composition and function can be resolved at the single-cell level in primary human tissues to help inform therapeutic strategies. |
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Translation neuroscience using human stem cell models of the brain and advanced informatics. |
7. Application of genomics in the clinic
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Our work centres on the morphogenic control of intestinal stem cell fate in health, regeneration and cancer and the preclinical application of novel therapies to manipulate this regulation. |
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We use viral vectors, which target the lung and liver, to deliver genes and gene editing molecules for treatment of rare diseases. |
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The BRC Genomic Medicine Theme’s research currently focuses on the application of targeted and whole genome sequencing (WGS) to the diagnosis of rare diseases and cancer, and investigation of novel genes emerging applying a range of functional approaches. |
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Prospective students can contact our supervisors directly to ask about specific projects of interest.