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A selection of recent publications with our GMS students as contributing authors, showing the breadth of the course and the successes of our students.


GWAS Identifies Risk Locus for Erectile Dysfunction and Implicates Hypothalamic Neurobiology and Diabetes in Etiology.

Am J Hum Genet. 2019 Jan 3;104(1):157-163. doi: 10.1016/j.ajhg.2018.11.004.



Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data.

Genome Med. 2019 Mar 26;11(1):19. doi: 10.1186/s13073-019-0628-8.



Ultrafast search of all deposited bacterial and viral genomic data.

Nat Biotechnol. 2019 Feb;37(2):152-159. doi: 10.1038/s41587-018-0010-1.



Decoupling tRNA promoter and processing activities enables specific Pol-II Cas9 guide RNA expression.

Nat Commun. 2019 Apr 2;10(1):1490. doi: 10.1038/s41467-019-09148-3.




A dynamic three-step mechanism drives the HIV-1 pre-fusion reaction.

Nat Struct Mol Biol. 2018 Sep;25(9):814-822. doi: 10.1038/s41594-018-0113-x.

(Nolan, Jabobsdottir)


Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.

Nat Genet. 2018 Nov;50(11):1505-1513. doi: 10.1038/s41588-018-0241-6. Epub 2018 Oct 8.



Identifying loci affecting trait variability and detecting interactions in genome-wide association studies.

Nat Genet. 2018 Nov;50(11):1608-1614. doi: 10.1038/s41588-018-0225-6.



Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains.

Nat Genet. 2018 Dec;50(12):1744-1751. doi: 10.1038/s41588-018-0253-2.

(Oudelaar, Schwessinger)


An Equivariant Bayesian Convolutional Network predicts recombination hotspots and accurately resolves binding motifs.

Bioinformatics. 2018 Nov 27. doi: 10.1093/bioinformatics/bty964.



Patterns of differential gene expression in a cellular model of human islet development, and relationship to type 2 diabetes predisposition.

Diabetologia. 2018 Jul;61(7):1614-1622. doi: 10.1007/s00125-018-4612-4.



The UK Biobank resource with deep phenotyping and genomic data.

Nature. 2018 Oct;562(7726):203-209. doi: 10.1038/s41586-018-0579-z.



Cellular diversity in the Drosophila midbrain revealed by single-cell transcriptomics.

Elife. 2018 Apr 19;7. pii: e34550. doi: 10.7554/eLife.34550.



Genomic and epidemiological monitoring of yellow fever virus transmission potential.

Science. 2018 Aug 31;361(6405):894-899. doi: 10.1126/science.aat7115. Epub 2018 Aug 23.




Sasquatch: predicting the impact of regulatory SNPs on transcription factor binding from cell- and tissue-specific DNase footprints.

Genome Res. 2017 Oct;27(10):1730-1742. doi: 10.1101/gr.220202.117.



Resolving the prevalence of somatic transposition in Drosophila.

Elife. 2017 Jul 25;6. pii: e28297. doi: 10.7554/eLife.28297.



Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice.

Am J Hum Genet. 2017 Feb 2;100(2):238-256. doi: 10.1016/j.ajhg.2017.01.011.



PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study.

Lancet Diabetes Endocrinol. 2017 Feb;5(2):97-105. doi: 10.1016/S2213-8587(16)30396-5.



Resolving plasmid structures in Enterobacteriaceae using the MinION nanopore sequencer: assessment of MinION and MinION/Illumina hybrid data assembly approaches.

Microb Genom. 2017 Jun 9;3(8):e000118. doi: 10.1099/mgen.0.000118.



A Phylogenetic Codon Substitution Model for Antibody Lineages.

Genetics. 2017 May;206(1):417-427. doi: 10.1534/genetics.116.196303. Epub 2017 Mar 17.



In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering.

Nat Commun. 2017 Dec 13;8(1):2109. doi: 10.1038/s41467-017-00686-2.



Robust detection of chromosomal interactions from small numbers of cells using low-input Capture-C.

Nucleic Acids Res. 2017 Dec 15;45(22):e184. doi: 10.1093/nar/gkx1194.



Establishment and cryptic transmission of Zika virus in Brazil and the Americas.

Nature. 2017 Jun 15;546(7658):406-410. doi: 10.1038/nature22401. Epub 2017 May 24.