Core 1 – Fundamentals in Human Genetics and Genomics
This module will introduce and teach fundamental principles in human genetics and genomics, providing a platform of knowledge for the rest of the course and enabling students to understand the basis of inheritance, variation and link with disease.
Core 2 – Genomics of Rare and Inherited Diseases
This module will introduce the disease phenotypes and molecular basis of common and rare inherited disease. Approaches and techniques to identify causal genes and variants. Genetic mapping strategies including linkage and genome-wide association. Role of epigenetics. The application of medical genetics and more widely genomic medicine for diagnosis, stratification and development of precision medicine approaches in research and clinical settings.
Core 3 – Bioinformatics, Statistics and Data Interpretation in Genomic Analysis
This module will equip students with the knowledge to understand the fundamental principles and basis of bioinformatics for data processing and analysis, critically appraise different bioinformatic methods, formulate research questions and understand professional best practice guidelines.
Core 4 - Omic Technologies and their Application to Genomic Medicine
This module will introduce current -omics technologies and their application to understand genome biology and disease in a research and clinical setting.
Elective A1 – Molecular Pathology and Precision Medicine
This module will introduce molecular pathology and how this is being informed and developed through genomics and related -omic technologies to allow better understanding of the basis of disease, the development of precision medicine approaches and novel therapies.
Elective A2 – Advanced Quantitative Methods (Bioinformatics & Statistics)
This module is designed for students wishing to gain a deeper knowledge and understanding of quantitative methods used in bioinformatic and statistical analysis of large scale and high dimensional -omic datasets.
Elective A3 – Genome Engineering and Gene-Based Therapeutics
This module will provide in depth content on the development and current applications of genome engineering. Mechanistic basis of programmable nucleases including ZFNs, TALENs and CRISPR/Cas9. Application in model systems and human cells to understand genome function and biology. Use of gene editing and gene-based therapeutics for human disease including haematological and retinal disease, cardiomyopathies.
Elective A4 – Single Cell Applications of -Omic Approaches
This module will focus on the use of single cell technologies to achieve unprecedented resolution at a cellular and tissue level for functional genomic and related -omic assays.
Elective B1 – Genomics in Clinical Practice
This module will provide more advanced learning in the clinical application of genomic medicine, focused on students who are health care practitioners. The content of the module will focus on practical experience of working with genomic data for diagnostic purposes, including whole genome sequencing for rare disease and cancer.
Elective B2 – Applications of Genomics in Therapeutics, Vaccinology and Industry
This module will focus on the translational use of genomics in drug development, vaccinology and biotech. The content will focus on the theory and application of pharmacogenomics to individualise drug therapy to the individual patient; the use of genetic and genomic data for drug target identification and prioritisation; application of genomics to enable patient stratification in clinical trials; development of personalised vaccines; targeted therapy and precision medicine.
The final term will focus on the main research project that each MSc student undertakes in a research group/laboratory of their choice for a 12 to 14 week period.