Transgenics Core
Genetically modified models provide a powerful method for the functional analysis of genes in vivo. The ability to introduce specific mutations into the genome allows models of human disease to be generated, facilitating insights into the pathophysiology of disease and providing a model with which therapeutic strategies and diagnostic tools can be optimized. Models can also be used to assess the functional significance of genetic variation.
Frequently utilizing the new site-specific nuclease technologies (CRISPR/Cas9, TALEN), our group can help develop engineered mouse models or cell lines. For overexpression studies, we employ a number of different techniques based on site-specific integration.
Our group provides groups within Oxford University access to key transgenic and reproductive technologies to allow the generation, distribution and cryopreservation of genetic models. Service is offered on a collaborative basis and as a fee-for-service type arrangement. Assistance can be provided at all levels, from basic strategy discussions and assistance in grant proposal preparationto full service generation of genetically modified models.
Services and activities
Generation of transgenic mouse models- Gene targeting in embryonic stem cells
- Generation of Knock-out and Knock-in models
- Generation of Rosa26 Knock-in mice
- Embryo transfer of strains for importing into the University
- Cryopreservation of strains
- Assisted reproduction
To contact us:
By Email: transgenics-group@well.ox.ac.uk
By Phone: +44 (0)1865 287500
by Fax: +44 (0)1865 287501