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The Core Staff carry out Fluorescence in situ Hybridization (FISH) experiments and chromosomal analysis for:

  • Verification of chromosomal location of clones/probes
  • Identification of chromosomal anomalies and analysis of candidate regions in patients or individuals who manifest some of the clinical symptoms of a specific disease
  • Characterisation of transgenic loci
  • Verification of cell lines authenticity; assessment of their chromosome content and gene copy number prior to molecular investigations
  • Validation of genome architecture and copy number variation (CNV) studies

As well as DNA-FISH, the portfolio of cytological techniques available in the Core comprises M-FISH, RNA-FISH, chromosome analysis & karyotyping, immunoFISH, immunocytochemistry, immunohistochemistry, and chromogenic RNA in situ hybridization on tissue.