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We aim to identify new disease mechanisms that could form the basis for new treatments. We are particularly interested in understanding how the immune system and inflammation are involved in the development of atherosclerosis and diabetes mellitus. These diseases are common and important and atherosclerosis is the major cause of death globally and an increasing problem even in poorer countries.


We aim to undertake research that will help us to develop better treatments for patients and improve our health service.

We study common conditions including atherosclerosis and vascular disease and seek to understand how different conditions such as diabetes, high blood pressure, heart disease, kidney disease and obesity can combine to cause health problems. Often these condition co-exist and result in multi-morbidity or frailty and we are working on how best to care for people in this situation and how best to organise this care. 

We use a wide range of research approaches to address these questions including molecular science, clinical studies and big data science. 

How to find us

Professor Chris O'Callaghan
Nuffield Department of Clinical Medicine,
Henry Wellcome Building,
University of Oxford,
Roosevelt Drive

How to find the campus, street map and campus map (building 8).

Our team