following the publication of the Lancet RespiratoryMedicine paper "Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study", The Lancet Respiratory Medicine, 4, 259-271 (2016).
This paper describes how an integrated functional genomics approach uncovered differences in the host response to pneumonia, identifying opportunities for personalised treatment. Following admission to intensive care, we found that transcriptomic analysis of peripheral blood leucocytes defines two distinct sepsis response signatures (SRS1 and SRS2). We resolved that a predictive set of seven genes enabled the classification of patients as SRS1 or SRS2. This has potential value as a biomarker as patients in the SRS1 group have a worse outcome.