Goh C, Knight JC, Lancet Respir Med. 2017 Mar;5(3):212-223. doi: 10.1016/S2213-2600(17)30045-0.
Omics-based approaches have facilitated understanding of the heterogeneous sepsis disease phenotype, but they are themselves currently limited by this heterogeneity. In this review article, we explore how unique characteristics attributable to individual pathogens affect the nature and consequences of interaction with the host in sepsis. We propose that achieving the goal of personalised treatment for individuals with sepsis will require researchers and clinicians to integrate studies of both pathogen and host.