Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

This is a research study that aims to understand the inherited causes of disease involving the immune system. We have discovered that differences in the DNA sequence may be associated with disease risk but we do not know which specific variants are important and how they may act.

In order to understand this further, we propose a functional genomics approach to study gene expression in blood cells from patients in order to resolve regulatory genetic variants. In particular, the Human Leukocyte Antigen (HLA) genes in the Major Histocompatibility Complex (MHC) on chromosome 6 have been extensively associated with immune related diseases, and so we are particularly focussing our study on different white blood cell types, where these genes are predominantly expressed.