The Hinch Group is interested in the biological mechanisms of recombination and mutation and their impacts on species and their evolution.
Our goal is to understand processes that impact DNA in the germ line and how they affect human health and diversity. Many of these processes, such as mutation and meiotic recombination, are complex and dynamic, involving the interplay of numerous proteins.
Our approach is data driven. We perform a range of experimental assays, including CRISPR-Cas9 mediated genome-editing, to learn how these proteins interact with the genome. We then use machine learning and other statistical techniques to unravel their complex choreography.
We also utilise large-scale genetic and phenotypic data in humans (e.g., UK Biobank) to understand their impacts on our health.
We have exciting wet-lab and computational opportunities in the lab and welcome DPhil students. For details of specific projects, please get in touch.
Hinch, A.G., Becker, P. W., Li, T., Moralli, D., Zhang, G., Bycroft, C., Green, C., Keeney, S., Shi, Q., Davies, B., and Donnelly, P. The configuration of RPA, RAD51 and DMC1 binding in meiosis reveals the nature of critical recombination intermediates. Molecular Cell. (2020).
Anjali G Hinch, Gang Zhang, Philipp W Becker, Daniela Moralli, Robert Hinch, Benjamin Davies, Rory Bowden, Peter Donnelly. Factors influencing meiotic recombination revealed by whole-genome sequencing of single sperm. Science. Vol. 363, Issue 6433 (2019).
Davies B, Hatton E, Altemose N, Hussin JG, Pratto F, Zhang G, Hinch AG, Moralli D, Biggs D, Diaz R, Preece C, Li R, Bitoun E, Brick K, Green CM, Camerini-Otero RD, Myers SR, Donnelly P. Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice. Nature. 530, 171-176 (2016).