The Hinch Group is interested in the biological mechanisms of recombination and mutation and their impacts on species and their evolution.
Our goal is to understand processes that impact DNA in the germline and how they affect human health and diversity. Many of these processes, such as mutation and meiotic recombination, are complex and dynamic, involving the interplay of numerous proteins.
We use statistical and computational techniques that combine data from multiple specialised assays to understand this interplay, often leveraging genetically modified model organisms. We also utilise large-scale genetic and phenotypic data in humans (e.g., UK Biobank) to understand the impacts of these processes.
We have exciting wet-lab and computational opportunities in the lab and welcome DPhil students. For details of specific projects, please get in touch.
Evrony, G.D., Hinch, A.G., Luo, C. Applications of Single-Cell DNA Sequencing. Annual Reviews of Genomics and Human Genetics. (2021).
Hinch, A.G., Becker, P. W., Li, T., Moralli, D., Zhang, G., Bycroft, C., Green, C., Keeney, S., Shi, Q., Davies, B., and Donnelly, P. The configuration of RPA, RAD51 and DMC1 binding in meiosis reveals the nature of critical recombination intermediates. Molecular Cell. (2020).
Anjali G Hinch, Gang Zhang, Philipp W Becker, Daniela Moralli, Robert Hinch, Benjamin Davies, Rory Bowden, Peter Donnelly. Factors influencing meiotic recombination revealed by whole-genome sequencing of single sperm. Science. Vol. 363, Issue 6433 (2019)..
Davies B, Hatton E, Altemose N, Hussin JG, Pratto F, Zhang G, Hinch AG, Moralli D, Biggs D, Diaz R, Preece C, Li R, Bitoun E, Brick K, Green CM, Camerini-Otero RD, Myers SR, Donnelly P. Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice. Nature. 530, 171-176 (2016).