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Publications

Discovery and pharmacophoric characterization of chemokine network inhibitors using phage-display, saturation mutagenesis and computational modelling

Vales S. et al, (2023), Nature Communications, 14

Calcitonin paracrine signaling controls heart fibrogenesis and arrhythmia

Moreira L. et al, (2022), JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 173, S85 - S86

Transcriptomic Analysis of Inflammatory Cardiomyopathy Identifies Molecular Signatures of Disease and Informs in silico Prediction of a Network-Based Rationale for Therapy.

Singh K. et al, (2021), Front Immunol, 12

Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia

Moreira LM. et al, (2020), Nature, 587, 460 - 465

Early Embryonic Expression of AP-2α Is Critical for Cardiovascular Development

Johnson A-L. et al, (2020), Journal of Cardiovascular Development and Disease, 7, 27 - 27

Engineered anti-inflammatory peptides inspired by mapping an evasin-chemokine interaction

Darlot B. et al, (2020), Journal of Biological Chemistry, jbc.RA120.014103 - jbc.RA120.014103

Characterization of a novel inhibitor of coagulation factor XIa identified from salivary gland transcripts of the lone star tick, Amblyomma americanum.

Mrinalini None. et al, (2020), Toxicon : official journal of the International Society on Toxinology, 177 Suppl 1

Using evasins to target the chemokine network in inflammation.

Bhattacharya S. and Kawamura A., (2020), Advances in protein chemistry and structural biology, 119, 1 - 38

Evasins: Tick Salivary Proteins that Inhibit Mammalian Chemokines

Bhusal RP. et al, (2019), Trends in Biochemical Sciences

Biowire Model of Interstitial and Focal Cardiac Fibrosis

Wang EY. et al, (2019), ACS Central Science, 5, 1146 - 1158

A knottin scaffold directs the CXC-chemokine–binding specificity of tick evasins

Lee AW. et al, (2019), Journal of Biological Chemistry, 294, 11199 - 11212

Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate

Gao R. et al, (2019), Cell Research, 29, 486 - 501

Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia

Gorman KM. et al, (2019), The American Journal of Human Genetics, 104, 948 - 956

IDENTIFICATION OF THE MAJOR GENETIC CONTRIBUTORS TO TETRALOGY OF FALLOT

Page DJ. et al, (2019), HEART, 105, A182 - A183

A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity

Dykes IM. et al, (2018), Scientific Reports, 8

Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets

Alenazi Y. et al, (2018), Scientific Reports, 8

Tetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation

Bailey J. et al, (2018), Scientific Reports, 8

The N-terminal domain of a tick evasin is critical for chemokine binding and neutralization and confers specific binding activity to other evasins

Eaton JRO. et al, (2018), Journal of Biological Chemistry, 293, 6134 - 6146

Pcsk5 is required in the early cranio-cardiac mesoderm for heart development

Szumska D. et al, (2017), BMC Developmental Biology, 17

Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities

Singh K. et al, (2017), Scientific Reports, 7

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