Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics.
Journal article
Ghoussaini M. et al, (2021), Nucleic acids research, 49, D1311 - D1320
CD70 expression determines the therapeutic efficacy of expanded human regulatory T cells
Journal article
Arroyo Hornero R. et al, (2020), Communications Biology, 3
Circulating C-peptide levels mirror patterns of residual beta cell mass in the pancreas of children and young people with type 1 diabetes
Conference paper
Carr ALJ. et al, (2020), DIABETOLOGIA, 63, S132 - S133
Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort.
Other
Thaventhiran JED. et al, (2020), Nature, 584
Whole-genome sequencing of a sporadic primary immunodeficiency cohort
Journal article
Thaventhiran JED. et al, (2020), Nature, 583, 90 - 95
Whole-genome sequencing of patients with rare diseases in a national health system.
Journal article
Turro E. et al, (2020), Nature, 583, 96 - 102
Author Correction: Approaches and advances in the genetic causes of autoimmune disease and their implications
Journal article
Inshaw JRJ. et al, (2020), Nature Immunology
Interleukin-2 Therapy of Autoimmunity in Diabetes (ITAD): a phase 2, multicentre, double-blind, randomized, placebo-controlled trial
Journal article
Marcovecchio ML. et al, (2020), Wellcome Open Research, 5, 49 - 49
Assessing the effect of closed-loop insulin delivery from onset of type 1 diabetes in youth on residual beta-cell function compared to standard insulin therapy (CLOuD study): a randomised parallel study protocol.
Journal article
Boughton C. et al, (2020), BMJ open, 10
Genetic Variants Predisposing Most Strongly to Type 1 Diabetes Diagnosed Under Age 7 Years Lie Near Candidate Genes That Function in the Immune System and in Pancreatic β-Cells.
Journal article
Inshaw JRJ. et al, (2020), Diabetes care, 43, 169 - 177
PRF1 mutation alters immune system activation, inflammation, and risk of autoimmunity
Journal article
Sidore C. et al, (2020), Multiple Sclerosis Journal
Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells and PD-1 Expression
Journal article
Ferreira RC. et al, (2019), Frontiers in Immunology, 10
The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes.
Journal article
Ramos-Rodríguez M. et al, (2019), Nature genetics, 51, 1588 - 1595
An integrated platform to systematically identify causal variants and genes for polygenic human traits
Journal article
Downes DJ. et al, (2019)
A genome-wide search for genes affecting the age-at-diagnosis of type 1 diabetes
Conference paper
Syreeni A. et al, (2019), DIABETOLOGIA, 62, S108 - S108
Genetic association analysis of type 1 diabetes in > 60,000 ancestrally diverse subjects: refinement of existing association signals and discovery of novel type 1 diabetes risk loci
Conference paper
Rich SS. et al, (2019), DIABETOLOGIA, 62, S107 - S107
Identification of infants with increased type 1 diabetes genetic risk for enrollment into Primary Prevention Trials-GPPAD-02 study design and first results.
Journal article
Winkler C. et al, (2019), Pediatric diabetes, 20, 720 - 727
Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data.
Journal article
Romagnoni A. et al, (2019), Scientific reports, 9
Oral insulin therapy for primary prevention of type 1 diabetes in infants with high genetic risk: the GPPAD-POInT (global platform for the prevention of autoimmune diabetes primary oral insulin trial) study protocol.
Journal article
Ziegler A-G. et al, (2019), BMJ open, 9
Publisher Correction: Approaches and advances in the genetic causes of autoimmune disease and their implications
Journal article
Inshaw JRJ. et al, (2019), Nature Immunology, 20, 375 - 375