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Relative Affinities of Protein–Cholesterol Interactions from Equilibrium Molecular Dynamics Simulations

Journal article

Ansell TB. et al, (2021), Journal of Chemical Theory and Computation

Structure and Mechanism of Hedgehog Acyl Transferase

Journal article

Coupland C. et al, (2021)

Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)*.

Journal article

Lanyon-Hogg T. et al, (2021), Angewandte Chemie (International ed. in English), 60, 13542 - 13547

Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.

Journal article

Robinson RA. et al, (2021), Cell, 184, 2103 - 2120.e31

The Energetics of Cholesterol Transport through Patched1: MD Simulations and Free Energy Calculations

Conference paper

Ansell TB. et al, (2021), BIOPHYSICAL JOURNAL, 120, 72A - 72A

Cholesterol access in cellular membranes controls Hedgehog signaling.

Journal article

Radhakrishnan A. et al, (2020), Nature chemical biology, 16, 1303 - 1313

Glypicans shield the Wnt lipid moiety to enable signalling at a distance.

Journal article

McGough IJ. et al, (2020), Nature

Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex.

Journal article

Malinauskas T. et al, (2020), Proceedings of the National Academy of Sciences of the United States of America, 117, 15620 - 15631

R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling.

Journal article

Dubey R. et al, (2020), eLife, 9

Cholesterol and Patched1: MD Simulation Studies

Conference paper

Ansell TB. et al, (2020), BIOPHYSICAL JOURNAL, 118, 363A - 363A

Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning

Journal article

Rozbesky D. et al, (2019), Nature Communications, 10

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling.

Journal article

Kinnebrew M. et al, (2019), eLife, 8

The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.

Journal article

Rudolf AF. et al, (2019), Nature chemical biology, 15, 975 - 982

iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition.

Journal article

Chen S. et al, (2019), Proceedings of the National Academy of Sciences of the United States of America, 116, 17470 - 17479

Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling.

Journal article

Kowatsch C. et al, (2019), Current opinion in structural biology, 57, 204 - 214

Biochemical mechanisms of vertebrate hedgehog signaling.

Journal article

Kong JH. et al, (2019), Development (Cambridge, England), 146

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