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Tigger elements are human DNA transposons homologous to the pogo element of Drosophila melanogaster. They contain an open reading frame for a transposase very similar to the major mammalian centromere protein CENP-B. We found in the horse genome a DNA element ( Ecatig3) sharing 88% homology with human Tigger3. The presence of Tigger elements in the horse genome confirms previous data that date these elements before the divergence between Perissodactyla and Primates (80-90 Myr ago). Copy number evaluation indicates that the horse element is much more abundant than its human counterpart. Southern blot analysis demonstrates that Ecatig3 elements are extremely homogeneous; this may indicate that the evolution of this DNA transposon has been driven by some kind of selection and has not been neutral.

Original publication

DOI

10.1007/s00335-004-3040-6

Type

Journal article

Journal

Mammalian genome : official journal of the International Mammalian Genome Society

Publication Date

05/2004

Volume

15

Pages

399 - 403

Addresses

Department of Genetics and Microbiology A. Buzzati Traverso, University of Pavia, Via Ferrata 1, 27100, Pavia, Italy.

Keywords

Fibroblasts, Animals, Horses, DNA, DNA Transposable Elements, Blotting, Southern, Evolution, Molecular, Base Sequence, Sequence Homology, Nucleic Acid, Gene Dosage, Genome, Molecular Sequence Data, Selection, Genetic