Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype
Migliorini G., Fiege B., Hosking FJ., Ma Y., Kumar R., Sherborne AL., da Silva Filho MI., Vijayakrishnan J., Koehler R., Thomsen H., Irving JA., Allan JM., Lightfoot T., Roman E., Kinsey SE., Sheridan E., Thompson P., Hoffmann P., Nöthen MM., Mühleisen TW., Eisele L., Zimmermann M., Bartram CR., Schrappe M., Greaves M., Stanulla M., Hemminki K., Houlston RS.
<jats:title>Key Points</jats:title> <jats:p>Variation at 10p12.2 (PIP4K2A) and 10p14 (GATA3) influences ALL risk and tumor subtype. GATA3 genotype is a determinant of event-free survivorship.</jats:p>