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<jats:title>ABSTRACT</jats:title><jats:p>OXA-48-like enzymes have emerged as important extended-spectrum β-lactamases/carbapenemases in<jats:named-content xmlns:xlink="http://www.w3.org/1999/xlink" content-type="genus-species" xlink:type="simple">Escherichia coli</jats:named-content>sequence type 131 (ST131). We report the structures of the first fully sequenced<jats:italic>bla</jats:italic><jats:sub>OXA-163</jats:sub>plasmid and of two other<jats:italic>bla</jats:italic><jats:sub>OXA-48</jats:sub>plasmids in this lineage.<jats:italic>bla</jats:italic><jats:sub>OXA-163</jats:sub>was located on a 71-kb IncN plasmid with other resistance genes.<jats:italic>bla</jats:italic><jats:sub>OXA-48</jats:sub>was present on IncL/M plasmids, genetically similar to other<jats:italic>bla</jats:italic><jats:sub>OXA-48</jats:sub>plasmid sequences, and consistent with interspecies/interlineage spread. The presence of<jats:italic>bla</jats:italic><jats:sub>OXA-48-like</jats:sub>genes on epidemic plasmids in ST131 is of concern.</jats:p>

Original publication

DOI

10.1128/aac.01130-16

Type

Journal article

Journal

Antimicrobial Agents and Chemotherapy

Publisher

American Society for Microbiology

Publication Date

11/2016

Volume

60

Pages

6948 - 6951