First Report ofblaIMP-14on a Plasmid Harboring Multiple Drug Resistance Genes in Escherichia coli Sequence Type 131
Stoesser N., Sheppard AE., Peirano G., Sebra RP., Lynch T., Anson LW., Kasarskis A., Motyl MR., Crook DW., Pitout JD.
<jats:title>ABSTRACT</jats:title><jats:p>The<jats:italic>bla</jats:italic><jats:sub>IMP-14</jats:sub>carbapenem resistance gene has largely previously been observed in<jats:named-content xmlns:xlink="http://www.w3.org/1999/xlink" content-type="genus-species" xlink:type="simple">Pseudomonas aeruginosa</jats:named-content>and<jats:named-content xmlns:xlink="http://www.w3.org/1999/xlink" content-type="genus-species" xlink:type="simple">Acinetobacter</jats:named-content>spp. As part of global surveillance and sequencing of carbapenem-resistant<jats:named-content xmlns:xlink="http://www.w3.org/1999/xlink" content-type="genus-species" xlink:type="simple">Escherichia coli</jats:named-content>, we identified a sequence type 131 strain harboring<jats:italic>bla</jats:italic><jats:sub>IMP-14</jats:sub>within a class 1 integron, itself nested within an ∼54-kb multidrug resistance region on an epidemic IncA/C<jats:sub>2</jats:sub>plasmid. The emergence of<jats:italic>bla</jats:italic><jats:sub>IMP-14</jats:sub>in this context in the ST131 lineage is of potential clinical concern.</jats:p>