Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases

Thinnes CC., Tumber A., Yapp C., Scozzafava G., Yeh T., Chan MC., Tran TA., Hsu K., Tarhonskaya H., Walport LJ., Wilkins SE., Martinez ED., Müller S., Pugh CW., Ratcliffe PJ., Brennan PE., Kawamura A., Schofield CJ.

<p>A Betti reaction was used for efficient generation of 2OG oxygenase inhibitors, including for KDM4 demethylases.</p>

DOI

10.1039/c5cc06095h

Type

Journal article

Journal

Chemical Communications

Publisher

Royal Society of Chemistry (RSC)

Publication Date

2015

Volume

51

Pages

15458 - 15461

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