Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor

England KS., Tumber A., Krojer T., Scozzafava G., Ng SS., Daniel M., Szykowska A., Che K., von Delft F., Burgess-Brown NA., Kawamura A., Schofield CJ., Brennan PE.

<p>Compound<bold>35</bold>is a potent and selective triazolopyridine inhibitor of the lysine demethylase KDM2A (pIC<sub>50</sub>7.2).</p>

DOI

10.1039/c4md00291a

Type

Journal article

Journal

Med. Chem. Commun.

Publisher

Royal Society of Chemistry (RSC)

Publication Date

2014

Volume

5

Pages

1879 - 1886

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