Common variants at 11p13 are associated with susceptibility to tuberculosis
Thye T., Owusu-Dabo E., Vannberg FO., Van Crevel R., Curtis J., Sahiratmadja E., Balabanova Y., Ehmen C., Muntau B., Ruge G., Sievertsen J., Gyapong J., Nikolayevskyy V., Hill PC., Sirugo G., Drobniewski F., Van De Vosse E., Newport M., Alisjahbana B., Nejentsev S., Ottenhoff THM., Hill AVS., Horstmann RD., Meyer CG.
After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10 -9). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10 -11. © 2012 Nature America, Inc. All rights reserved.