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Gestational diabetes mellitus (GDM) is associated with increased risk of pregnancy complications and adverse perinatal outcomes. GDM often reoccurs and is associated with increased risk of subsequent diagnosis of type 2 diabetes (T2D). To improve our understanding of the aetiological factors and molecular processes driving the occurrence of GDM, including the extent to which these overlap with T2D pathophysiology, the GENetics of Diabetes In Pregnancy Consortium assembled genome-wide association studies of diverse ancestry in a total of 5485 women with GDM and 347 856 without GDM. Through multi-ancestry meta-analysis, we identified five loci with genome-wide significant association (P 

Original publication

DOI

10.1093/hmg/ddac050

Type

Journal article

Journal

Human molecular genetics

Publication Date

09/2022

Volume

31

Pages

3377 - 3391

Addresses

Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu 51010, Estonia.

Keywords

Humans, Diabetes, Gestational, Diabetes Mellitus, Type 2, Genetic Predisposition to Disease, Glucose, Pregnancy, Polymorphism, Single Nucleotide, Female, Genome-Wide Association Study