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The publication of More Genes Direct by the Human Genetics Commission is a timely reminder of the potential impact that 'over-the-counter' genetic testing (that is, a direct genetic test without the need for a medical referral) may have on the NHS. This article considers the relevance of current genetic research on complex common diseases and how this might translate into risk estimates for developing conditions such as dementia, cancer, and cardiovascular disease. The implications for primary care include the need to understand the current limitations of genetic testing and its commercial application over the counter, and the importance of continuing to make risk assessments using family history. The authors recommend caution in the premature introduction of over-the-counter testing without a sound evidence base.

Original publication

DOI

10.3399/bjgp09x395021

Type

Journal article

Journal

The British journal of general practice : the journal of the Royal College of General Practitioners

Publication Date

04/2009

Volume

59

Pages

283 - 287

Addresses

St George's, University of London, Department of Community Health Sciences (General Practice), Cranmer Terrace, London SW17 0RE. irafi@sgul.ac.uk

Keywords

Humans, Genetic Predisposition to Disease, Attitude to Health, Physician's Role, Genetic Counseling, Family Practice, Forecasting, Genetic Testing