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AimThe relevance of the cytidine diphosphate-choline and Rho GTPases pathways in the pathogenesis of cancer has been previously demonstrated. We investigate by a case-control association study if genetics variants in these pathways are associated with risk of developing lung cancer.MethodsThirty-seven tag SNPs were evaluated as risk factor of NSCLC in 897 cases and 904 controls.ResultsSix SNPs were nominally associated with lung cancer risk, which were not significant after the Bonferroni correction for multiple comparisons. No association was observed with the remaining 31 analyzed SNPs, neither it was found significant in haplotype frequencies.ConclusionsAlthough the implication of the two pathways investigated in our study in carcinogenesis is well established, our null results suggest that common genetic variants in CDP-choline and Rho GTPases-related genes are not risk factors for lung cancer.

Original publication

DOI

10.1007/s12094-013-1080-7

Type

Journal article

Journal

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

Publication Date

01/2014

Volume

16

Pages

107 - 112

Addresses

Division of Translational Oncology, Health Research Institute and University Hospital Fundación Jiménez Díaz, Madrid, Spain, arancha.cebrian@fjd.es.

Keywords

Humans, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Genetic Predisposition to Disease, rho GTP-Binding Proteins, Choline Kinase, Phospholipids, Haplotypes, Polymorphism, Single Nucleotide, Aged, Middle Aged, Female, Male