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IntroductionMalnutrition is a common problem in cancer patients. Its incidence varies according to disease stage (between 15 and 90%) and is considered a possible prognostic factor for therapeutic response and survival. It is also one of the causes contributing to the increase in morbidity and mortality in patients. Tumor cachexia is defined as a nutritional defect caused by tumor growth in the patient and presents as a significant weight loss. This weight loss is mainly caused by a degradation of skeletal muscle proteins.ConclusionThe ubiquitin-proteasome system is the most important pathway of protein degradation. As a regulatory system governing protein half-life, it is involved in the regulation of the cell cycle, signal transmission, immune system response, apoptosis, and oncogenesis. Knowledge of the molecular pathways involved in the induction of cancer-associated cachexia will favor a more rational approach to its treatment as well as possible quality of life and survival benefit for the patient.

Original publication

DOI

10.1007/s00520-006-0097-7

Type

Journal article

Journal

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Publication Date

12/2006

Volume

14

Pages

1173 - 1183

Addresses

Servicio de Oncología Médica, Consorcio Hospital General Universitario de Valencia, Av. Tres Cruces s/n, 46014, Valencia, Spain. camps_car@gva.es

Keywords

Humans, Neoplasms, Syndrome, Cachexia, Anorexia, Proteasome Endopeptidase Complex, Proteoglycans, Tumor Necrosis Factor-alpha, Ubiquitin, Signal Transduction