Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The inheritance of particular alleles of major histocompatibility complex class II genes increases the risk for various human autoimmune diseases; however, only a small percentage of individuals having an allele associated with susceptibility develop disease. The identification of allelic variants more precisely correlated with disease susceptibility would greatly facilitate clinical screening and diagnosis. Oligonucleotide-primed gene amplification in vitro was used to determine the nucleotide sequence of a class II variant found almost exclusively in patients with the autoimmune skin disease pemphigus vulgaris. In addition to clinical implications, the disease-restricted distribution of this variant should provide insight into the molecular mechanisms underlying associations between diseases and HLA-class II genes.

Original publication

DOI

10.1126/science.2894075

Type

Journal article

Journal

Science (New York, N.Y.)

Publication Date

02/1988

Volume

239

Pages

1026 - 1029

Addresses

Department of Medical Microbiology, Stanford University, CA 94305.

Keywords

Humans, Pemphigus, Autoimmune Diseases, DNA, HLA-D Antigens, HLA-DQ Antigens, HLA-DR Antigens, Nucleic Acid Hybridization, Gene Amplification, Base Sequence, Polymorphism, Restriction Fragment Length, Alleles, Molecular Sequence Data, Genetic Variation