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The existence of "active" and "reserve" stem cell populations in the intestinal epithelium has been debated since 1977. Now in Cell Stem Cell, Murata et al. (2020) show that all intestinal regeneration arises from daughter cell dedifferentiation, marking the coming-of-age of the regenerative stem cell plasticity model.

Original publication

DOI

10.1016/j.stem.2020.02.003

Type

Journal article

Journal

Cell stem cell

Publication Date

03/2020

Volume

26

Pages

301 - 302

Addresses

Intestinal Stem Cell Biology Laboratory, Wellcome Centre Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK. Electronic address: simon.leedham@well.ox.ac.uk.

Keywords

Intestines, Intestinal Mucosa, Stem Cells, Cell Dedifferentiation, Cell Plasticity