Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Tamoxifen treatment in breast cancer patients is associated with increased risk of endometrial malignancies. Significantly, higher AGR2 expression was found in endometrial cancers that developed in women previously treated with tamoxifen compared to those who had not been exposed to tamoxifen. An association of elevated AGR2 level with myometrial invasion occurrence and invasion depth was also found. In vitro analyses identified a stimulatory effect of AGR2 on cellular proliferation. Although adverse tamoxifen effects on endometrial cells remain elusive, our work identifies elevated AGR2 as a candidate tamoxifen-dependent mechanism of action responsible for increased incidence of endometrial cancer.

Original publication

DOI

10.1080/07357907.2017.1309546

Type

Journal article

Journal

Cancer investigation

Publication Date

05/2017

Volume

35

Pages

313 - 324

Addresses

a Masaryk Memorial Cancer Institute , RECAMO , Brno , Czech Republic.

Keywords

Endometrium, Humans, Adenocarcinoma, Endometrial Neoplasms, Cell Transformation, Neoplastic, Neoplasm Invasiveness, Tamoxifen, Proteins, Antineoplastic Agents, Hormonal, Risk Factors, Retrospective Studies, Transfection, Signal Transduction, Cell Proliferation, Cell Movement, RNA Interference, Up-Regulation, Female, MCF-7 Cells, A549 Cells