Visiting Postdoctoral Clinical Research Fellow
I am now an Academic Clinical Fellow at the London School of Hygiene and Tropical Medicine and a Specialty Registrar in infectious diseases and general medicine at University College Hospital, London. Before this I spent a number of years at the Wellcome Trust Centre for Human Genetics where I completed my doctoral research as a Medical Research Council Clinical Research Training Fellow under the supervision of Professor Adrian Hill in Oxford in conjunction with Associate Professor Andrew Steer at the University of Melbourne.
The main focus of my research is investigating host genetic susceptibility to group A streptococcal disease especially rheumatic heart disease. The main project I did while in Oxford was a genome-wide association of susceptibility to rheumatic heart disease set in the Pacific. More details, including information about access to data, are available here. Building on this work, I now chair the Analysis Committee of the International Rheumatic Heart Disease Genetics Consortium.
The other major project I did while in Oxford was an exome sequencing study of susceptibility severe streptococcal infections with a particular focus on group A streptococcal necrotising fasciitis in otherwise healthy individuals. Undertaken in collaboration with Public Health England and Imperial College London, this project recruited individuals from the UK with the help of the Lee Spark NF Foundation. More details are available here.
I have a wide variety of other research interests related to rheumatic heart disease including measuring disease burden in low resource settings using record-linkage. More details are available here.
A Novel Framework for Characterizing Genomic Haplotype Diversity in the Human Immunoglobulin Heavy Chain Locus
Rodriguez OL. et al, (2020), Frontiers in Immunology, 11
Cross-sectional study of population-specific streptococcal antibody titres in Uganda
Okello E. et al, (2020), Archives of Disease in Childhood, 105, 825 - 829
Active Case Finding for Rheumatic Fever in an Endemic Country
Okello E. et al, (2020), Journal of the American Heart Association, 9
Native American gene flow into Polynesia predating Easter Island settlement
Ioannidis AG. et al, (2020), Nature, 583, 572 - 577
The cost-of-illness due to rheumatic heart disease: national estimates for Fiji
Heenan RC. et al, (2020), Transactions of The Royal Society of Tropical Medicine and Hygiene, 114, 483 - 491