Wellcome Centre for Human Genetics
|Structure-based classification of paramyxoviral attachment glycoproteins reflects receptor specificity.|
Professor of Structural Biology
Structural biology of antibodies and viral glycoproteins
Glycoproteins feature on the surface of many enveloped viruses, and as such, are attractive targets for therapeutic design. Through the application of techniques in structural biology, immunology, and cell biology, our group aims to harness knowledge of glycoprotein structure and function to inform upon the rational development of therapeutics and preventive medicines. We have a particular interest in the development and characterisation of neutralising and protective monoclonal antibodies and look to apply the insights gleaned from our biophysical studies to identify sites of vulnerability that may be targeted through rational vaccine design.
Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein.
Rissanen I. et al, (2020), eLife, 9
A structural basis for antibody-mediated neutralization of Nipah virus reveals a site of vulnerability at the fusion glycoprotein apex.
Avanzato VA. et al, (2019), Proceedings of the National Academy of Sciences of the United States of America
Unraveling virus relationships by structure-based phylogenetic classification
Ng WM. et al, (2020), Virus Evolution, 6
A Protective Monoclonal Antibody Targets a Site of Vulnerability on the Surface of Rift Valley Fever Virus
Allen ER. et al, (2018), Cell Reports, 25, 3750 - 3758.e4
Idiosyncratic Mòjiāng virus attachment glycoprotein directs a host-cell entry pathway distinct from genetically related henipaviruses
Rissanen I. et al, (2017), Nature Communications, 8