Patrick K. Albers
In my thesis research, I focus on studying the evolutionary history of genetic variation in the human genome, as it is of considerable relevance for complex disease research. Much of this interest derives from several aspects; (a) the recent technological advances which allow to study human genetic information in unprecedented detail, (b) the understanding that low frequency variants may play a significant role in disease susceptibility, (c) the appreciation that genes involved in the aetiology of a genetic disorder are likely to carry non-neutral evolutionary signatures, and (d) the fact that rare variants accumulated in recent evolutionary times in the human genome, marking them as informative for both population genetics and human disease research.
I am a member of both the McCarthy group and the McVean group.
My interest concerns rare genetic variation and its impact on complex disease. I want to integrate population genetic analyses with applications in disease-association of rare variants. The goal of my research is to develop the framework that allows to estimate the age of rare variants across different populations, to infer signals of (deleterious) selection that may have affected protein function and the disease phenotype in question.
I plan to develop the methodology necessary to work with (protein-coding) sequence data obtained from type 2 diabetes (T2D) cases and controls in multi-ethnic cohorts, and to characterise differences of the genetic architecture underlying this complex disease.
Imputation and association studies
Genetics of complex diseases
Sponsor: Wellcome Trust
Patrick is an organiser of Quantitative Genomics 2016 student conference