Nadia is a DPhil student, working mainly on colitis and colitis-associated colorectal cancer, looking into the link between inflammation and tumourigenesis.
Individuals suffering from inflammatory bowel disease (IBD) are at a significantly increased risk of developing colon cancer. Colitis-associated colorectal cancer (CA-CRC) is both phenotypically and molecularly different from sporadic colorectal cancer.
In consideration of this, her work focuses on:
- Understanding the stem cell dynamics of colitis-associated lesions
- Undertaking an integrated omics analysis of colitis-associated progressor lesions and sporadic lesions, to determine whether molecular characterization of colitis affected bowel tissue can aid determine further cancer risk.
- Elucidating the carcinogenic pathway of colitis-associated colorectal cancer, particularly looking into the WNT signalling pathway
Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia.
Vasquez EG. et al, (2022), Cell stem cell, 29, 1213 - 1228.e8
Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas
Heino S. et al, (2021), Science Advances, 7
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.
Flanagan DJ. et al, (2021), Nature, 594, 430 - 435
A Quantitative Evolutionary Approach Utilising High Resolution Chromosomal Copy Number Analysis Accurately Stratifies Patients with Ulcerative Colitis and Low Grade Dysplasia by Future Colorectal Cancer Risk
Al Bakir I. et al, (2019), JOURNAL OF PATHOLOGY, 249, S12 - S12
QUANTIFYING EVOLUTION OF EARLY DYSPLASTIC LESIONS IN ULCERATIVE COLITIS PREDICTS FUTURE COLORECTAL CANCER RISK
Curtius K. et al, (2019), GASTROENTEROLOGY, 156, S162 - S163