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Nadia Nasreddin

Nadia is a DPhil student, working mainly on colitis and colitis-associated colorectal cancer,  looking into the link between inflammation and tumourigenesis.

Individuals suffering from inflammatory bowel disease (IBD) are at a significantly increased risk of developing colon cancer. Colitis-associated colorectal cancer (CA-CRC) is both phenotypically and molecularly different from sporadic colorectal cancer.

In consideration of this, her work focuses on:

- Understanding the stem cell dynamics of colitis-associated lesions

- Undertaking an integrated omics analysis of colitis-associated progressor lesions and sporadic lesions, to determine whether molecular characterization of colitis affected bowel tissue can aid determine further cancer risk.

- Elucidating the carcinogenic pathway of colitis-associated colorectal cancer, particularly looking into the WNT signalling pathway