Nadia is a DPhil student, working mainly on colitis and colitis-associated colorectal cancer, looking into the link between inflammation and tumourigenesis.
Individuals suffering from inflammatory bowel disease (IBD) are at a significantly increased risk of developing colon cancer. Consequently, IBD patients are subjected to intensive and expensive surveillance programs, aiming to detect precursor lesions in their early developmental stages. However, the effectiveness of these programs is compromised by several factors, including the difficulty in detecting dysplastic lesions at endoscopy.
In consideration of this, the project she is working on consists in undertaking an integrated omics analysis of colitis-associated progressor lesions and sporadic lesions, to determine whether molecular characterization of colitis affected bowel tissue can aid determine further cancer risk. Furthermore, she would like to elucidate the carcinogenic pathway of colitis-associated colorectal cancer, particularly looking into the WNT signalling pathway.
A Quantitative Evolutionary Approach Utilising High Resolution Chromosomal Copy Number Analysis Accurately Stratifies Patients with Ulcerative Colitis and Low Grade Dysplasia by Future Colorectal Cancer Risk
Al Bakir I. et al, (2019), JOURNAL OF PATHOLOGY, 249, S12 - S12
QUANTIFYING EVOLUTION OF EARLY DYSPLASTIC LESIONS IN ULCERATIVE COLITIS PREDICTS FUTURE COLORECTAL CANCER RISK
Curtius K. et al, (2019), GASTROENTEROLOGY, 156, S162 - S163