Matteo Ferla
My interest lies with the structural side of protein: how do they function and what effects are mutations having on them?
My role within the group is to try to understand what are the structural effects of various mutations found by the HICF2 WGS sequencing programme and to interface with the Structural Genomics Consortium. This is a fascinating work as every protein has a different story to tell, each with their own secrets and challenges. In fact, only couple of cases have a straightforward delta-Gibbs change that unravels them, instead the effect range from catalytic or interface to altered sorting motifs.
Personal site: www.matteoferla.com
Github: github.com/matteoferla
Blog: blog.matteoferla.com/
Twitter: https://twitter.com/matteoferla
Recent publications
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Michelanglo: sculpting protein views on web pages without coding.
Journal article
Ferla MP. et al, (2020), Bioinformatics (Oxford, England)
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Identification of Circulating Genomic and Metabolic Biomarkers in Intrahepatic Cholangiocarcinoma
Journal article
Winter H. et al, (2019), Cancers, 11, 1895 - 1895
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Delineation of dominant and recessive forms of
LZTR1
‐associated Noonan syndrome
Journal article
Pagnamenta AT. et al, (2019), Clinical Genetics, 95, 693 - 703
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Directed Evolution of Proteins Based on Mutational Scanning.
Chapter
Acevedo-Rocha CG. et al, (2018), 1685, 87 - 128
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Evolving Accelerated Amidation by SpyTag/SpyCatcher to Analyze Membrane Dynamics
Journal article
Keeble AH. et al, (2017), Angewandte Chemie, 129, 16748 - 16752