My interest lies with the structural side of protein: how do they function and what effects are mutations having on them?
My role within the group is to try to understand what are the structural effects of various mutations found by the HICF2 WGS sequencing programme and to interface with the Structural Genomics Consortium. This is a fascinating work as every protein has a different story to tell, each with their own secrets and challenges. In fact, only couple of cases have a straightforward delta-Gibbs change that unravels them, instead the effect range from catalytic or interface to altered sorting motifs.
Personal site: www.matteoferla.com
Michelanglo: sculpting protein views on web pages without coding.
Ferla MP. et al, (2020), Bioinformatics (Oxford, England)
Identification of Circulating Genomic and Metabolic Biomarkers in Intrahepatic Cholangiocarcinoma
Winter H. et al, (2019), Cancers, 11, 1895 - 1895
Delineation of dominant and recessive forms of
‐associated Noonan syndrome
Pagnamenta AT. et al, (2019), Clinical Genetics, 95, 693 - 703
Directed Evolution of Proteins Based on Mutational Scanning.
Acevedo-Rocha CG. et al, (2018), 1685, 87 - 128
Evolving Accelerated Amidation by SpyTag/SpyCatcher to Analyze Membrane Dynamics
Keeble AH. et al, (2017), Angewandte Chemie, 129, 16748 - 16752