I am currently studying the population genetics of the platypus, using whole-genome sequence (WGS) data to learn about demographic history, recombination and selection. I am also working on aspects of the WGS500 project, a large medical sequencing project at the Centre, focusing on some Mendelian neurological diseases, particularly early infantile epilepsies.
Before coming to Oxford, I worked at various times on miRNA targeting, the evolution of gene regulation in yeast, and the effects of the environment on human gene expression.
Martin HC, Christ R, Hussin JG, O'Connell J, Gordon S, Mbarek H, Hottenga JJ, McAloney K, Willemsen G, Gasparini P, Pirastu N, Montgomery GW, Navarro P, Soranzo S, Toniolo D, Vitart V, Wilson JF, Marchini J, Boomsma DI, Martin NG, Donnelly P. Multi-cohort analysis of the maternal age effect on recombination. Nature Communications 6, Article number: 7846 doi:10.1038/ncomms8846.
Martin HC, Taylor JC, …, the WGS500 Consortium, …, Donnelly P, McVean G. Factors influencing success of clinical genome sequencing across a broad spectrum of disorders. Nature Genetics (published online 18 May 2015)
Martin HC, Kim GE, Pagnamenta AT, Murakami Y, Carvill GL, et al. Clinical whole-genome sequencing in severe early-onset epilepsy reveals new genes and improves molecular diagnosis. Hum Mol Genet. 2014; Feb 11, epub ahead of print, PMID: 24463883.
From previous projects:
Martin HC, Wani S, Steptoe AL, Krishnan K, Nones K, Nourbakhsh E, Vlassov A, Grimmond SM, Cloonan N. Imperfect centered miRNA binding sites are common and can mediate repression of target mRNAs. Genome Biol. 2014;15(3):R51.
Krishnan K, Steptoe AL, Martin HC, Pattabiraman DR, Nones K, Waddell N, Mariasegaram M, Simpson PT, Lakhani SR, Vlassov A, Grimmond SM, Cloonan N. miR-139-5p is a regulator of metastatic pathways in breast cancer. RNA. 2013 Dec;19(12):1767-80. doi: 10.1261/rna.042143.113.
Martin HC, Roop JI, Schraiber JG, Hsu TY, Brem RB. Evolution of a membrane protein reglon in Saccharomyces. Mol Biol Evol. 2012;29(7):1747-56. doi: 10.1093/molbev/mss017. Epub 2012 Jan 20.
Cloonan N, Wani S, Xu Q, et al. MicroRNAs and their isomiRs function cooperatively to target common biological pathways. Genome Biol. 2011;12(12):R126. doi: 10.1186/gb-2011-12-12-r126.
Krishnan K, Steptoe AL, Martin HC, et al. RNA. MicroRNA-182-5p targets a network of genes involved in DNA repair. 2013;19(2):230-42. doi: 10.1261/rna.034926.112. Epub 2012 Dec 18.