Associate Professor of Cardiovascular Science
Large studies linking common variations to the occurrence of coronary artery disease have enabled us to identify several new genes that may have a causative influence on the susceptibility to developing coronary artery disease. However, for many of these genes the mechanism by which they alter cardiovascular disease pathology is unknown.
Cardiomyocyte tetrahydrobiopterin synthesis regulates fatty acid metabolism and susceptibility to ischaemia–reperfusion injury
Chu SM. et al, (2023), Experimental Physiology
Endothelial cell-specific roles for tetrahydrobiopterin in myocardial function, cardiac hypertrophy, and response to myocardial ischemia-reperfusion injury
Chuaiphichai S. et al, (2023), American Journal of Physiology-Heart and Circulatory Physiology, 324, H430 - H442
Endothelial cell vasodilator dysfunction mediates progressive pregnancy-induced hypertension in endothelial cell tetrahydrobiopterin deficient mice.
Chuaiphichai S. et al, (2023), Vascul Pharmacol, 150
Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2
Broadway-Stringer S. et al, (2023), Cells, 12, 721 - 721