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Contact information

Email
gillian.douglas@cardiov.ox.ac.uk

DPHIL OPPORTUNITIES AVAILABLE

Douglas Group - Functional coronary artery disease genetics - defining the function of new causal atherosclerosis genes from CAD GWAS loci using in vitro and in vivo models

Gillian Douglas

PhD

Associate Professor of Cardiovascular Science

Large studies linking common variations to the occurrence of coronary artery disease have enabled us to identify several new genes that may have a causative influence on the susceptibility to developing coronary artery disease. However, for many of these genes the mechanism by which they alter cardiovascular disease pathology is unknown.

Recent publications

Cardiomyocyte tetrahydrobiopterin synthesis regulates fatty acid metabolism and susceptibility to ischaemia–reperfusion injury
Journal article

Chu SM. et al, (2023), Experimental Physiology
Endothelial cell-specific roles for tetrahydrobiopterin in myocardial function, cardiac hypertrophy, and response to myocardial ischemia-reperfusion injury
Journal article

Chuaiphichai S. et al, (2023), American Journal of Physiology-Heart and Circulatory Physiology, 324, H430 - H442
Endothelial cell vasodilator dysfunction mediates progressive pregnancy-induced hypertension in endothelial cell tetrahydrobiopterin deficient mice.
Journal article

Chuaiphichai S. et al, (2023), Vascul Pharmacol, 150
Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2
Journal article

Broadway-Stringer S. et al, (2023), Cells, 12, 721 - 721

More publications