Anjali Gupta Hinch
I am interested in germline DNA metabolism. I work on understanding the biological mechanisms of recombination and mutation and their impacts on species and their evolution.
Hinch, A.G., Becker, P. W., Li, T., Moralli, D., Zhang, G., Bycroft, C., Green, C., Keeney, S., Shi, Q., Davies, B., and Donnelly, P. The configuration of RPA, RAD51 and DMC1 binding in meiosis reveals the nature of critical recombination intermediates. Molecular Cell. (2020) doi:10.1016/j.molcel.2020.06.015 [Link].
Yamada, S., Hinch, A. G., Kamido, H., Zhang, Y., Edelmann, W., Keeney, S. (2020). Molecular structures and mechanisms of DNA break processing in mouse meiosis. Genes and Development. 10.1101/gad.336032.119 [Link].
Anjali G Hinch, Gang Zhang, Philipp W Becker, Daniela Moralli, Robert Hinch, Benjamin Davies, Rory Bowden, Peter Donnelly. Factors influencing meiotic recombination revealed by whole-genome sequencing of single sperm. Science. Vol. 363, Issue 6433, eaau8861 (2019). [Link].
Davies B, Hatton E, Altemose N, Hussin JG, Pratto F, Zhang G, Hinch AG, Moralli D, Biggs D, Diaz R, Preece C, Li R, Bitoun E, Brick K, Green CM, Camerini-Otero RD, Myers SR, Donnelly P. Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice. Nature. 530, 171-176 (2016). [Link].
Anjali G Hinch, Nicolas Altemose, Nudrat Noor, Peter Donnelly, Simon R Myers. Recombination in the Human Pseudoautosomal Region PAR1. PLoS Genetics 10(7): e1004503 (2014). [Link].
Altering the Binding Properties of PRDM9 Partially Restores Fertility across the Species Boundary
Davies B. et al, (2021), Molecular Biology and Evolution
ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair
Wells D. et al, (2020), eLife, 9
The Configuration of RPA, RAD51, and DMC1 Binding in Meiosis Reveals the Nature of Critical Recombination Intermediates
Hinch AG. et al, (2020), Molecular Cell, 79, 689 - 701.e10
Molecular structures and mechanisms of DNA break processing in mouse meiosis.
Yamada S. et al, (2020), Genes & development, 34, 806 - 818
Factors influencing meiotic recombination revealed by whole-genome sequencing of single sperm
Hinch AG. et al, (2019), Science, 363, eaau8861 - eaau8861