Anjali Gupta Hinch

Work summary

I am interested in germline DNA metabolism. I work on understanding the biological mechanisms of recombination and mutation and their impacts on species and their evolution.

Selected publications

Hinch, A.G., Becker, P. W., Li, T., Moralli, D., Zhang, G., Bycroft, C., Green, C., Keeney, S., Shi, Q., Davies, B., and Donnelly, P. The configuration of RPA, RAD51 and DMC1 binding in meiosis reveals the nature of critical recombination intermediates. Molecular Cell.  (2020) doi:10.1016/j.molcel.2020.06.015 [Link].

Yamada, S., Hinch, A. G., Kamido, H., Zhang, Y., Edelmann, W., Keeney, S. (2020). Molecular structures and mechanisms of DNA break processing in mouse meiosis. Genes and Development. 10.1101/gad.336032.119 [Link].

Anjali G Hinch, Gang Zhang, Philipp W Becker, Daniela Moralli, Robert Hinch, Benjamin Davies, Rory Bowden, Peter Donnelly. Factors influencing meiotic recombination revealed by whole-genome sequencing of single sperm. Science. Vol. 363, Issue 6433, eaau8861 (2019). [Link].

Davies B, Hatton E, Altemose N, Hussin JG, Pratto F, Zhang G, Hinch AG, Moralli D, Biggs D, Diaz R, Preece C, Li R, Bitoun E, Brick K, Green CM, Camerini-Otero RD, Myers SR, Donnelly P. Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice. Nature. 530, 171-176 (2016). [Link].

Anjali G Hinch, Nicolas Altemose, Nudrat Noor, Peter Donnelly, Simon R Myers. Recombination in the Human Pseudoautosomal Region PAR1. PLoS Genetics 10(7): e1004503 (2014). [Link].

Anjali G Hinch, Arti Tandon, Nick Patterson, Yunli Song, Nadin Rohland, Cameron D Palmer, et al. The landscape of recombination in African Americans. Nature. 2011; 476: 170-175.[Link] [Materials].