I am currently working on detecting copy number variation in targeted sequencing data using a Bayesian statistical approach. My focus is on identifying large variants in genes which have known associations with cancer, such as BRCA1 and BRCA2. This work is in collaboration with the Institute of Cancer Research and forms part of the Mainstreaming Cancer Genetics Programme which aims to integrate genetic testing into routine cancer patient care.
Anna Fowler, Vilas Menon, and Nicholas A. Heard. Dynamic Bayesian clustering. J. Bioinform. Comput. Biol. 11, 1342001, 2013.
Anna Fowler, and Nicholas A. Heard. On two-way Bayesian agglomerative clustering of gene expression data. Statistical Analysis and Data Mining 5: 463-476, 2012.