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Genetics of Complex Traits in Model OrganismsGauguier groupCreation and Characterization of Genetic and Genomic Resources in the RatThe rat provides the most relevant model for the accurate analysis of whole organism, organ and cellular phenotypes relevant to human complex disorders. Genetic studies in experimental crosses derived from inbred rat models have identified nearly 150 quantitative trait loci (QTL) involved in the control of complex phenotypes. Rat genetic and genomic resources have rapidly improved to support the fine mapping of rat QTLs and the identification of disease susceptibility genes at these loci. Dense linkage and radiation hybrid maps have been produced based on the genetic and/or physical mapping of more than 20,000 microsatellite markers and gene/EST sequences. Rat genomic libraries (YAC, PAC and BAC) have been generated for physical mapping. Knowledge of synteny conservation and disruption between the rat, mouse and human genomes is essential for the identification of candidate regions in the human genome that are homologous to rat quantitative trait loci (QTL) and can be subsequently tested for evidence of linkage and association in appropriate human family collections. Comparative maps derived in our laboratory are based on the integration of approximately 2,000 markers associated with known rat genes in our linkage and/or radiation hybrid maps of the rat. Our Rat Genetic/Genomic Database provides information on microsatellite markers, including polymorphism data between inbred rat strains, linkage and/or radiation hybrid maps, gene maps and comparative genome analysis, physical mapping data and links to other data repositories. Enter our Rat Genetic/Genomic Database
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